Solid-State Testing and Analysis

XtalPi’s Rational Drug Design and Development Experimental Center offers a variety of chemical solid state characterization services, including X-ray diffractometer (XRD), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Dynamic vapor sorption analysis (DVS), and Hot stage microscopy (HSM).

X-ray Powder Diffraction (XRPD)

Each crystalline form has its unique X-ray diffraction pattern, and XRPD is a conventional method to characterize crystalline samples.

Indexing of Powder Diffraction Data (Indexing)

The parameters of the crystal cell can be detailly obtained by inverting the XRPD data of a single crystal form to acquire more comprehensive information from the sample.

Differential Scanning Calorimetry(DSC)

DSC is a common method to determine melting, recrystallization, decomposition and glass state transformation in pharmaceutical research.

Thermogravimetric Analysis(TGA)

TGA is commonly used to measure the weight change with temperature and can determine the sample thermodynamic properties with DSC data.

Hot Stage Optical Microscope(HSM)

Hot stage optical microscopy (HSM) can observe the sample appearance change such as melting and recrystallization in response to environmental temperature. Data can be recorded by photos or videos.

Dynamic Vapor Sorption Analysis (DVS)

DVS is used to measure the weight change of the sample in response to humidity and can determine the sample hygroscopicity, the formation of hydrate crystal form, and the stability of hydrate crystal form.

Karl Fischer Titrator

The moisture titrator is used to measure the water content in the hydrate crystal form and can determine the hygroscopicity of the sample.

High-Performance Liquid Chromatography

HPLC can be used to determine the chemical purity, stability, and solubility of the samples.